Looking at the diagram, we see that each position in the bottom row contains a square of dots. The side length of each square matches the number of dots in the shape directly above it in the top row:
In the first column, the top row has 1 dot, and the bottom row has a 1×1 square (1 dot).
In the second column, the top row has 2 dots, and the bottom row has a 2×2 square (4 dots).
In the third column, the top row has 4 dots, and the bottom row has a 4×4 square (16 dots).
So, the pattern is: The bottom row has a square of dots, with side length equal to the number of dots in the top row.
For the fourth column, the top row has 8 dots. So, the bottom row should have an 8×8 square of dots.
Calculating the total number of dots:
Therefore, the question mark should be replaced with 64 dots.
Otherwise, you might realize that the bottom row of dots is quadrupling between columns. Then, you can identify that the square before the question mark contains 16 dots, so the missing square would have 4⋅16, or 64 dots. Both solutions are equally valid.